Moore was born and raised in Portland, Oregon, where he attended Benson Polytechnic High School. He went to Mt. Hood Community College in Gresham, Oregon for two years. In 1998 he transferred to Southern Oregon University in Ashland, Oregon where he earned his Bachelor of Fine Arts degree and performed for two summers at the Oregon Shakespeare Festival. In 2000, he moved to Los Angeles and reunited with his agent from Portland, Rachelle Ryan, who is now a manager in Los Angeles.

Starting his career in commercials, he has been in over 15 nationals (including eBay, Cingular Wireless, and Best Buy). Moore shot an international campaign for a branch of Siemens cell phones, XELIBRI, which won a Lion Award. Moore's most-recognizable roles may be in Dodgeball: A True Underdog Story, Hatchet , Grandma's Boy and Avatar.

Moore has appeared in nearly a dozen television shows, including: LAX, CSI, The Guardian, Strong Medicine, Six Feet Under, Angel, Providence, Boomtown, Boston Public, and House, and most recently as Colin Fisher, a graduate student on Bones. Moore's first film released in 2008 was a starring role in the romantic comedy The Hottie and the Nottie, followed by a lead role in James Cameron's Avatar (2009), opposite Sigourney Weaver and Sam Worthington. Moore also starred alongside Katy Perry in her music video for "Waking Up in Vegas" and made a cameo in the "Beat It" cover video from Fall Out Boy.